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inflammasome

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00:55 Oct 27, 2021
English to Malay translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Chemistry; Chem Sci/Eng, Medical: Pharmaceuticals
English term or phrase: inflammasome
Definition from Oxford English Dictionary:
A complex of proteins in the cytoplasm that regulates the activation of enzymes involved in immune and inflammatory responses to pathogens.

Example sentence(s):
  • Appropriate inflammasome activation is vital for the host to cope with foreign pathogens or tissue damage, while aberrant inflammasome activation can cause uncontrolled tissue responses that may contribute to various diseases, including autoinflammatory disorders, cardiometabolic diseases, cancer and neurodegenerative diseases. Nature Portfolio
  • The adaptor protein ASC must become linearly ubiquitinated and phosphorylated for inflammasome assembly to occur. After priming, canonical NLRP3 inflammasome activation requires a second, distinct signal to activate NLRP3 and lead to the formation of the NLRP3 inflammasome complex. National Center for Biotechnology Info
  • Potassium ion efflux (a common inflammasome activator) is an essential factor for the assembly and up-regulation of NLRP3 complexes induced by the agonist adenosine triphosphate (ATP). Molecular Cancer
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Question posted on behalf of translation team:
GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
5inflammasom
AAAS


  

Translations offered


7 hrs   confidence: Answerer confidence 5/5
inflammasom


Definition from intermediapub:
Inflammasom adalah platform multiprotein besar yang menterjemahkan pengiktirafan 'bahaya' ke dalam pengaktifan pro-caspase-1. Caspase-1 pada gilirannya proteolytically mengaktifkan prekursor sitokin pro-inflamasi IL-1β dan IL-18, yang dirembeskan untuk menyokong tindak balas keradangan.

Example sentence(s):
  • Laluan inflammasom penting dalam penyakit kronik; Walau bagaimanapun, ia tidak diketahui bagaimana isyarat itu dikekalkan selepas permulaan. Pengaktifan inflammasom bergantung kepada rangsangan seperti lipopolysaccharide (LPS) dan ATP yang menyediakan dua isyarat tersendiri yang mengakibatkan pengeluaran cepat interleukin (IL) -1β, dengan kekurangan respon untuk merangsang rangsangan. - legatechnics.com  
  • Pyroptosis adalah satu lagi mekanisme bunuh diri yang diprogramkan yang proinflamasi dan menyebabkan pecah secara tiba-tiba membran plasma dan lisis sel diikuti dengan pengaktifan inflammasom melalui jangkitan mikrob. - mldunbound.org  
  • Sesetengah kajian telah mendedahkan sebahagian daripada laluan kimia yang terlibat, mengenal pasti set bahan kimia yang perlu dirembeskan untuk mencetuskan pengeluaran IL-1beta. Kunci proses ini adalah koleksi protein yang dikenali sebagai inflammasom, yang sendiri diaktifkan oleh pelbagai bahan kimia lain. - Medic-life.com  
AAAS
Local time: 00:11
Native speaker of: Native in MalayMalay
PRO pts in category: 12
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