"The drug development process can be streamlined by combining the traditionally separate stages of dose-finding (Phase IIb) and confirmation of efficacy and safety (Phase III) using an adaptive seamless design".
E' un approccio di trial clinico che combina la Fase II (necessaria per capire la dose giusta del farmaco) e la fase III (per capire l'efficacia e la sicurezza del farmaco).

"A seamless design is a clinical trial design which combines into a single trial objectives which are traditionally addressed in separate trials, for example combination of dose selection with confirmation into one trial."


Si passa da una fase all'altra "senza interruzione di continuità"

Propongo "approccio/disegno adattativo seamless" http://www.hpg23.it/img/upload/files/sezione_1844_Dall_ipote...