English to Russian Medical Medical (general) psychiatry

Consistent with earlier publications from our group (Raison and Miller, 2012, 2013; Miller and Raison, 2015), we refer to this constellation of ideas as the pathogen–host defense theory of depression, or PATHOS-D. This position overlaps, but has significant differences from a pathogen defense theory of depression first articulated by Kinney and Tanaka, (2009) (Anders et al, 2013). Table 1 situates PATHOS-D within other possible explanatory frameworks for understanding why MDD and alterations in immune function should be related. Supplementary Table S1 provides a comparison of different adaptive explanations for the persistence of MDD and its risk alleles in human populations. As with all theories, the value of PATHOS-D will eventually be determined by its ability to make novel predictions and to provide coherent and parsimonious explanations for a wider range of variables than are accounted for by competing hypotheses. Our aim in this review is to evaluate PATHOS-D by these criteria. To do this, we list a series of concepts consistent with PATHOS-D theory, in each case evaluating the evidence for and against the theory's explanatory and predictive potential. In addition, we explore the theory's possible explanations for sex differences in the prevalence of MDD. In all these areas, we are careful to note the degree of data in support of each idea, and which ideas are frankly speculative. Figure 1 provides a graphic representation of epidemiological, biological, and genetic domains relevant to MDD that are addressed by PATHOS-D.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143499/