English to Russian Medical Medical: Pharmaceuticals

1)по идее все эти словосочетания должны переводиться ОДНИМ термином поэтому я объединил их в один вопрос
2)в кон-текстах ниже термины выделены астериксами *
3) Thank you in advance !

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This invention relates to devices and methods for local drug delivery, and in particular is directed to an implantable system that once is hermetically sealed to an organ or tissue protects a therapeutic agent intended for delivery to a *target tissue* from exposure to surrounding tissues and fluids while still achieving sustained levels, regionally or systemically, in a mammalian organism, methods for implanting same, and methods and devices for treating diseases.
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[U. S. PATENTS 6,251, 090; 5,830, 173 AND 5,725, 493, TO AVERY ET AL. , DESCRIBE A] drug delivery device, comprising a refillable reservoir connected to the vitreous cavity through a tube. This concept requires intraocular invasion, which limits its application to situations when the integrity of the *targeted tissue* is not an issue.
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Among the drug-related factors are: narrow difference in the efficacious-toxic concentration; high instability or susceptibility to inactivation before reaching the *aimed tissue*; the requirement of prolonged and steady release curves, particularly in chronic diseases; and availability in liquid or gel state. The tissue factors are mainly related to the level of topographic specificity that is required from that agent, and not less importantly to the harms and susceptibility of the surrounding tissues to the drug toxic effects.