Sep 17, 2021 13:16
2 yrs ago
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английский term
PHARMACY - LIFE SCIENCES
Native in: русский
Works in: английский => русский, русский => английский
pM
английский => русский
Медицина
Медицина: Фармацевтика
Table 5.1-4. Overview of PF-07104091 Safety Pharmacology Program
Study
Ex Vivo Studies
Rat Isolated
Aorta Study Isolated Guinea
Concentration or Dose
169 pM-30 *pM*
0.01-30 pM
In the ex vivo cardiovascular studies, the most potent PF-07104091 activity had an IC50 = 10 μM which is 20x the projected unbound Cmax at the clinical starting dose of 75 mg BID. In the 1-month pivotal GLP dog toxicity study, no cardiovascular effects were observed up to 30 mg/kg/day, giving a safety margin of 5.4x based on the total Cmax (see Table 5.1-2).
Study
Ex Vivo Studies
Rat Isolated
Aorta Study Isolated Guinea
Concentration or Dose
169 pM-30 *pM*
0.01-30 pM
In the ex vivo cardiovascular studies, the most potent PF-07104091 activity had an IC50 = 10 μM which is 20x the projected unbound Cmax at the clinical starting dose of 75 mg BID. In the 1-month pivotal GLP dog toxicity study, no cardiovascular effects were observed up to 30 mg/kg/day, giving a safety margin of 5.4x based on the total Cmax (see Table 5.1-2).
Proposed translations
(русский)
| 3 +1 | пМ |
Evgeni Kushch
|
Proposed translations
+1
6 мин
Evgeni Kushch
Украина
Украина
Native in русский
Specializes in field
Украина
MD with 12+ years in medical translation
Native in: русский (Variant: Standard-Russia) 
, украинский (Variant: Standard-Ukraine)
Works in: английский => русский, английский => украинский, русский => английский, and 3 more.
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пМ
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